InFamous: Second Son tells the story of Delsin Rowe, a 24 year old native of the Akomish tribe located outside of Seattle, Washington. Set seven years after the events of InFamous 2, the world has been exposed and made aware of the potential threat of conduits. Now labelled as Bio-terrorists, a government funded operation known as the Department of Unified Protection (D.U.P) is enforcing the control and suppression of conduits.
When a bus transporting a few conduits crashes, Delsin and his brother Reggie do what they can to help those trapped in the wreckage. During the rescue, as Delsin pulls a man from the vehicle he discovers that he is a conduit and is capable of absorbing other conduit’s powers.
The crash provides an opportunity for some of the conduits to escape and gain their freedom. Following the crash the D.U.P arrive to contain the situation and concluding a failed interrogation of a powered up Delsin, D.U.P head Augustine mortally injures members of the Akomish tribe attempting to extract the information she desires. This drives Delsin and Reggie to head to D.U.P temporary headquarters in Seattle to set things straight.